A preventable teratology: isotretinoin

Medical Malpractice: A Preventable or Inevitable Issue

Improving bioavailability with a novel isotretinoin formulation (isotretinoin-Lidose).

Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. Isotretinoin-Lidose (Epuris™), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on novel lipid encapsulation technology (Lidose®) to enclose isotretinoin, thereby increasing drug absorption during fasted ...

In vitro teratology.

The purpose of this conference was to reevaluate the need for and use of in vitro teratology assays; to examine the validation process for in vitro tests; and to discuss progress in the validation of in vitro teratology screens. Participants enthusiastically supported further development of short-term in vivo and in vitro systems both as prescreens for developmental toxicity and as experimental...

The teratology of autism.

Autism spectrum disorders affect behaviors that emerge at ages when typically developing children become increasingly social and communicative, but many lines of evidence suggest that the underlying alterations in the brain occur long before the period when symptoms become obvious. Studies of the behavior of children in the first year of life demonstrate that symptoms are often detectable in th...

Basic Concepts in Teratology

Given this inherent complexity, the text is remarkably well integrated and presents a balanced picture of current knowledge and questions. As in any book written by many authors, the style and quality of chapters vary, but the overall quality of writing is very good. The chapters by Milton Hildebrand ("Walking and Running"), James L. Edwards ("Terrestrial Locomotion Without Appendages"), and Jo...